ALOPECIA UNIVERSALIS

What is Alopecia Universalis?

The most advanced form in a series of conditions all related to the same disease, Alopecia Universalis (AU) is characterized by total a loss of body hair. A member of the group of hair loss conditions called Alopecia Areata, the only difference between Alopecia Universalis and its variants is the extent of hair loss.

Alopecia Universalis Symptoms

Normally, sufferers are otherwise healthy, but are more likely than the general population to experience thyroid disease and vitiligo (patchy loss of skin color). Those with vitiligo may eventually develop AU over time. Many individuals with Alopecia Universalis are born with some hair but begin losing it very quickly. The disorder is inherited as an autosomal recessive trait. It is caused by a mutation in a gene dubbed HR in chromosome band 8p21.2 — the human version of the gene that is responsible for hairlessness in mice.

Is the “hairless” gene only found in people with alopecia universalis? Most likely. Based on the known research, we can safely assume that only individuals with this rare and severe form of alopecia areata carry the gene. Unfortunately, there have not been enough studies to verify that this is true of all those afflicted. Aside from genetic tendencies, the contributing causes of Alopecia Universalis are not known.

As lack of body hair leaves areas like the scalp, eyes and nasal cavity particularly vulnerable, it is important that those with Alopecia Universalis take extra care to protect themselves from the sun, bacteria and other potentially harmful elements.

Fingernails and toenails can also be affected. Symptoms in the nails can range from pinprick-like indentations to severe distortion of the entire nail. Alopecia Universalis may be acute and short-lived or remain permanently. Regrowth is always a possibility, even for those with 100% hair loss over many years. However, it is not possible to predict when regrowth will occur.

Causes of Alopecia Universalis

In 1998, a researcher named M. Ahmad and his team of colleagues studied a family in which alopecia universalis was present in three consecutive generations. The afflicted children in the family showed no other health problems; however, skin biopsies from their scalps showed very few hair follicles. Of the follicles present, few contained hair shafts.

Researchers established that there were no other inflammatory conditions present to inhibit hair growth. The subjects were born without eyebrows or eyelashes and never developed them. They also never developed underarm or pubic hair.

Researchers analyzed the chromosomes of all 7 individuals with AU to detect genetic similarities. They found a marker at the location 8p12, consistent in all 7 subjects, but were unable to determine exactly which gene was at this location.

As a result, they hypothesized that there may be a genetic similarity in hairless mice which might match the one they found in the humans. Fortunately, there were several examples of alopecia in mice. They cloned the mouse hairless gene and used the mouse sequence to make PCR primers. They then used these primers on cDNA made from the mRNA of human skin fibroblasts. This identified a cDNA sequence which gave them the coding sequence of the human “hairless” gene. In humans and mice, this gene is expressed in the skin and brain. (The brain function of the gene is not known). It appears to encode a zinc-finger transcription factor. A mutation was found to be present in the “hairless” genes of all the affected individuals in the family that was studied.

Alopecia Universalis Treatment Scams

It is important to beware of the many companies out there claiming they can regrow hair for those with AU. In our research, we have happened upon several web sites on the Internet which claim (even with photographs) that they’ve regrown a full head of hair for AU patients. Please be a cautious and skeptical consumer, as the chances of these treatments being legitimate are a million to one. If they truly worked, the whole world would know about them.

Legitimate Alopecia Universalis Treatments

Some swear by aromatherapy, but there is little or no evidence to support that it works. The standard method of treatment is Topical Immunotherapy, which involves producing an allergic reaction with irritants placed onto the skin. The theory behind this method is based on the general knowledge that hair can be stimulated into growth sometimes, simply by irritating the follicles. Chemicals such as Diphencyprone (DPCP) or Squaric acid Dibutyl ester (SADBE) are applied to the scalp. About 40% of patients treated with topical Immunotherapy will regrow scalp hair after about six months of treatment. Treatment must be continued in order to maintain the hair, or until the disease has run it’s course.

Head Coverings for Alopecia Universalis

Since treatments for advanced forms of Alopecia like AU are less effective, a wig may be a good option for you. Believe it or not, there are many companies which offer undetectable wigs for these uses, as well as for chemotherapy patients. Make sure your provider is willing to cut, thin, and style the wig often for you, and provides sufficient adhesive for your more active days. Some wigs come with suction caps which attach directly to the wig. They’re a little more expensive, but are worth the investment.